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Orf 

Orf
Chapter:
Orf
Author(s):

David A. Warrell

DOI:
10.1093/med/9780199204854.003.070527_update_001

Update:

Prevention—live attenuated virus vaccines.

Updated on 31 May 2012. The previous version of this content can be found here.
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date: 11 December 2017

Orf (‘ecthyma contagiosum’) is caused by an epitheliotropic parapox DNA virus of sheep and goats that is able to subdue the host’s immune response. It is an occupational zoonosis of people working with these animals. A painful papule/pustule develops, usually on a finger, the site of contact with lesions on the animal’s muzzle. Systemic effects are unusual, but include local lymphadenopathy, fever, erythema multiforme, and other generalized rashes. Spontaneous resolution within 6 weeks is usual. Multiple, giant lesions may develop in the immunosuppressed. Topical cidofovir is effective in severe cases....

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