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Flaviviruses excluding dengue 

Flaviviruses excluding dengue

Chapter:
Flaviviruses excluding dengue
Author(s):

E.E. Ooi

, L.R. Petersen

, and D.J. Gubler

DOI:
10.1093/med/9780199204854.003.070514_update_001

Update:

New flaviviruses.

Epidemiology and ecology—new information on vector and reservoir species.

Updated on 31 May 2012. The previous version of this content can be found here.
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date: 26 June 2017

Flaviviruses, family Flaviviridae, are enveloped viruses with a single-strand positive-sense RNA genome approximately 11 kb in length. They comprise 53 species (40 of which can cause human infection), divided into three major groups based on epidemiology and phylogenetics. They are maintained in nature in complex transmission cycles involving a variety of animals and hematophagous arthropods, which transmit infection to humans. IgM antibody capture enzyme-linked immunosorbent assay (MAC-ELISA) is widely used for diagnosis, with confirmation requiring a four-fold or greater rise in specific antibodies between acute and convalescent serum samples, virus isolation, detection of specific antigen by immunohistochemistry or of viral RNA by nucleic acid amplification from blood or other tissue sample....

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