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Physiological changes, clinical features, and general management of infected patients 

Physiological changes, clinical features, and general management of infected patients
Chapter:
Physiological changes, clinical features, and general management of infected patients
Author(s):

Todd W. Rice

and Gordon R. Bernard

DOI:
10.1093/med/9780199204854.003.070102_update_001

July 30, 2015: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

New proinflammatory cytokines IL-17 and macrophage migration inhibitory factor.

Immunosuppression in late sepsis.

Procoagulant-anticoagulant and inflammatory interactions.

Vasopressin—role in septic shock.

Role of corticosteroid insufficiency and low-dose corticosteroid therapy.

Withdrawal of drotrecogin alfa (activated) or recombinant human activated protein C.

Failure of eritoran tetrasodium, anti-Toll-like receptor (TLR)-4.

Updated on 31 May 2012. The previous version of this content can be found here.
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date: 17 November 2017

The host response to an infectious stimulus involves an intricate link between the inflammatory and coagulation systems, also mechanisms designed to limit damage to normal tissues. Key elements are: (1) the inflammatory cascade—antigens from infectious agents stimulate macrophages and monocytes (and other cells) via Toll-like receptors to release tumour necrosis factor ...

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