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Cancer immunity and clinical oncology 

Cancer immunity and clinical oncology

Chapter:
Cancer immunity and clinical oncology
Author(s):

Maries van den Broek

, Lotta von Boehmer

, Kunle Odunsi

, and Alexander Knuth

DOI:
10.1093/med/9780199204854.003.0604

May 30, 2013: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

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date: 19 August 2017

Patients develop immune-mediated defence mechanisms against cancers, which are referred to as the ‘three E’s’: (1) elimination—corresponding to immunological control of the tumour or immunosurveillance; (2) equilibrium—the process by which the immune response iteratively selects/promotes less immunogenic tumour variants; and (3) escape—when the immunologically sculptured tumour expands in an uncontrolled manner....

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