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The genetics of inherited cancers 

The genetics of inherited cancers
Chapter:
The genetics of inherited cancers
Author(s):

Rosalind A. Eeles

DOI:
10.1093/med/9780199204854.003.0603

July 30, 2015: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

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date: 11 December 2017

All cancer can be termed ‘genetic’ as cancer is caused by somatic cell mutations (alterations in the DNA code), which result in abnormal cellular growth and/or proliferation. Most of these mutations are sporadic (only occurring in the cancer cell), but some are due to the inheritance of a germ-line mutation in a cancer predisposition gene....

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