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The nature and development of cancer 

The nature and development of cancer

Chapter:
The nature and development of cancer
Author(s):

John R. Benson

and Siong-Seng Liau

DOI:
10.1093/med/9780199204854.003.0602
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date: 28 June 2017

Contemporary ideas of carcinogenesis envisage a series of random genetic changes that confer a selective growth advantage over healthy cells. These changes collectively lead to the disruption of coordinated networks of intercellular communication and cause a fundamental change in cellular behaviour which affects processes such as proliferation, differentiation, and apoptosis. This progressive dysregulation of cellular function implies that cancer is not a morphological entity, but a process in which the malignant phenotype is gradually acquired....

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