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Immunodeficiency 

Immunodeficiency

Chapter:
Immunodeficiency
Author(s):

D. Kumararatne

DOI:
10.1093/med/9780199204854.003.0502_update_001

Update:

Classification of primary immunodeficiency states.

Immunoglobulin replacement therapy—discussion of dosage.

Mendelian susceptibility to mycobacterial disease—molecular basis of novel immunodeficiency characterized by monocytopenia and dendritic cell deficiency.

Clinical consequences of complement deficiency.

Chronic mucocutaneous candidiasis—clinical description and recent advances in understanding of pathogenesis.

Updated on 30 Nov 2011. The previous version of this content can be found here.
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date: 22 August 2017

Immunodeficiency is caused by failure of a component of the immune system and results in increased susceptibility to infections. The possibility that a patient has an underlying immunodeficiency should be considered in the following circumstances: (1) serious, persistent, unusual or recurrent infections; (2) failure to thrive in infancy; (3) known family history of immunodeficiency; (4) unexplained lymphopenia in infancy; (5) combination of clinical features characteristic of a particular immunodeficiency syndrome. The nature of the microbial infection in a particular patient provides a clue to the likely cause of immunodeficiency....

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