Show Summary Details
Page of

The mGluR Theory of Fragile X Syndrome 

The mGluR Theory of Fragile X Syndrome

Chapter:
The mGluR Theory of Fragile X Syndrome
Author(s):

Dilja D. Krueger

and Mark F. Bear

DOI:
10.1093/med/9780195371826.003.0080
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2015. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy).

date: 26 June 2017

Fragile X Syndrome (FXS) is a single-gene disorder associated with mental retardation and autism that is caused by loss of expression of the fragile X mental retardation protein (FMRP). The “mGluR theory of fragile X” postulates that FMRP and group I metabotropic glutamate receptors (mGluRs) act in functional opposition to regulate protein synthesis at the synapse, with mGluRs activating and FMRP repressing translation of FMRP target mRNAs. This chapter first briefly introduces FMRP and metabotropic glutamate receptors. It reviews the current state of knowledge on the mGluR theory at the level of basic, preclinical, and clinical research. It then discusses the questions that remain to be addressed to ensure that pharmacological interventions based on the mGluR theory have the greatest possible chance of succeeding in clinical trials and providing safe and effective treatments for patients with FXS.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.