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Autism and Environmental Genomics: Synergistic Systems Approaches to Autism Complexity 

Autism and Environmental Genomics: Synergistic Systems Approaches to Autism Complexity

Chapter:
Autism and Environmental Genomics: Synergistic Systems Approaches to Autism Complexity
Author(s):

Mark A. Corrales

and Martha R. Herbert

DOI:
10.1093/med/9780195371826.003.0056
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date: 09 December 2016

This chapter outlines how genetic and environmental factors may converge on common mechanisms pertinent to neurodevelopmental disorders, and the ways that high heritability can involve not only high genetic but also high environmental contributions. The chapter is organized as follows. Part One discusses the mechanisms by which genome and environment work together. Part Two considers the methodological pitfalls in assessing relative contributions of genes, environment, and gene-environment interactions in a disorder with high heritability. Part Three focuses on research directions and resources.

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