Show Summary Details
Page of

Autism as a Quantitative Trait 

Autism as a Quantitative Trait

Chapter:
Autism as a Quantitative Trait
Author(s):

John N. Constantino

DOI:
10.1093/med/9780195371826.003.0033
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2015. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy).

date: 29 March 2017

This chapter discusses the following: genetic mechanisms underlying quantitative traits; quantitative variation in autistic symptomatology in affected families; the factoral structure of quantitative autistic traits; quantitative variation in autistic symptomatology in the general population; the clinical ascertainment of autistic severity; intergenerational transmission of quantitative autistic traits; other implications of a quantitative structure for autism; quantitative autistic traits and endophenotypes; and the interface between social impairment and general cognition. The deficits that characterize autistic syndromes—including those in the current diagnostic criterion domains of reciprocal social behavior, social communication and repetitive behavior/restricted interests—are continuously distributed in nature and may share common underlying genetic and neural mechanisms. Integrating quantitative approaches to characterization of neurodevelopmental syndromes will help advance the search for genetic, psychologic neurobiologic and endophenotypic components of their underlying cause(s), and provides a basis for repeated-measurement strategies that can track developmental course and response to intervention.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can''t find the answer there, please contact us.