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Interface Between Autism Spectrum Disorders and Obsessive-Compulsive Behaviors: A Genetic and Developmental Perspective 

Interface Between Autism Spectrum Disorders and Obsessive-Compulsive Behaviors: A Genetic and Developmental Perspective

Chapter:
Interface Between Autism Spectrum Disorders and Obsessive-Compulsive Behaviors: A Genetic and Developmental Perspective
Author(s):

Suma Jacob

, Angeli Landeros-Weisenberger

, and James F. Leckman

DOI:
10.1093/med/9780195371826.003.0020
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date: 20 August 2017

This chapter reviews studies on the interface between autism spectrum disorders (ASD) and obsessive-compulsive behavior (OCB). The currently available data suggest that, with few exceptions, ASD is typically a multidimensional, polygenic disorder in which the effects of individual genes are much smaller than previously thought. This implies that in a majority of cases, ASD vulnerability is determined by a multiplicity of genes interacting with specific environmental risk factors over the course of development. One of the relevant phenotypes within the broader ASD phenotype is OCB. Like ASD itself, the etiologies of OCB are likely to prove to be multidimensional and polygenic, and significant progress is being made in assessing the relevant symptom domains (and neuropsychological endophenotypes) and their interrelationship with the family of vulnerability genes that underlie obsessive-compulsive disorder and related disorders.

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