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Invention and Development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH 

Invention and Development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH
Chapter:
Invention and Development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH
Author(s):

Peter J. Basser

DOI:
10.1093/med/9780195369779.003.0047
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date: 18 December 2018

This chapter documents the invention and early development of diffusion tensor (DT) NMR and MRI. It recounts personal experiences with former NIH colleagues—Denis Le Bihan and James Mattiello—from the initial conception of diffusion tensor NMR, to the definition of the apparent diffusion tensor, to the design of the first experiment to measure it. Descriptions of the state of the art in characterizing anisotropic diffusion at the time suggest the significant departure that DT-NMR and DT-MRI represented. Personal recollections and observations are woven through this account of the heady early days of DT-NMR and DT-MRI.

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