Show Summary Details
Page of

Cognitive Concerns 

Cognitive Concerns
Chapter:
Cognitive Concerns
Author(s):

M. Angela O’Neal

DOI:
10.1093/med/9780190609917.003.0030
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2015. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy).

date: 23 November 2017

This chapter reviews the incidence and gender-specific risks for women developing Alzheimer’s disease, AD. The incidence of AD doubles every five years beginning at age 60. Furthermore, AD is 2–3 times more common in women. Observational trials suggested that estrogen could play a role in delaying the onset of AD. However, the Women’s Health Initiative Memory Study, WHIMS, published in 2003, demonstrated that estrogen, with or without medroxyprogesterone, substantially increased the risk of dementia of any cause, with AD being the most frequent etiology. Additional studies suggesting that there might be a window where hormonal therapy is beneficial have not been corroborated. The gender differences in AD may be partially explained by the finding that women have less ability to clear amyloid. This results in a larger amyloid burden. Maintaining a healthy lifestyle is the only clearly documented preventative treatment for AD.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.