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A Mother Who Could Not See Her Baby 

A Mother Who Could Not See Her Baby
Chapter:
A Mother Who Could Not See Her Baby
Author(s):

Marcelo Matiello

, and Tamara B. Kaplan

DOI:
10.1093/med/9780190609917.003.0027
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date: 22 September 2017

Neuromyelitis optica spectrum disorders (NMOSD) belong to a group of relapsing neurological syndromes characterized by significant morbidity and mortality due to central nervous system (CNS) inflammation and necrosis. Most patients are seropositive for pathogenic antibodies targeting Aquaporin-4, and while this water channel is mostly expressed on the foot processes of astrocytes, it is also expressed in placental tissues. On planning a pregnancy, patients should be well informed about the increased risk of preeclampsia and miscarriages, and that most medications used to treat NMOSD have potentially severe toxicities to the fetus. There is also increased risk of relapses in the postpartum period, and immunosuppressive agents are the mainstream method of preventing attacks.

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