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A Woman with Weight Gain and Fatigue 

A Woman with Weight Gain and Fatigue
Chapter:
A Woman with Weight Gain and Fatigue
Author(s):

Alexandra Lovett

, and Whitney W. Woodmansee

DOI:
10.1093/med/9780190609917.003.0011
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date: 21 September 2017

Cushing’s syndrome is a descriptive term of a syndrome secondary to elevated levels of steroids or cortisol, while Cushing’s disease is hypercortisolemia that results from an adrenocorticotropic (ACTH)-secreting pituitary adenoma. Patients will present with cushingoid features on physical examination and can be myopathic with proximal rather than distal muscle weakness. Diagnosis can be obtained by multiple avenues including but not limited to checking 24 hour urine cortisol, a dexamethasone suppression test, checking ACTH levels, a CRH (corticotrophin-releasing hormone) stimulation test, and inferior petrosal sinus sampling (IPSS). Once Cushing’s disease is confirmed, treatment is via transsphenoidal resection of the pituitary adenoma.

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