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Research Design and Analysis 

Research Design and Analysis
Chapter:
Research Design and Analysis
Author(s):

Christian B. Ramers

DOI:
10.1093/med/9780190493097.003.0051
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date: 15 December 2018

Accurate interpretation of research literature is important as advances are made in the diagnosis and treatment of HIV and its complications. Because of inherent differences in approach, the on-treatment analysis will frequently report better outcomes than will the intent-to-treat analysis. The concept of time-to-loss of virologic response has been replaced by SNAPSHOT analysis as the preferred method of efficacy analysis by the US Food and Drug Administration. New antiretroviral therapy regimens are usually compared to existing standard-of-care regimens using a type of statistical comparison called a non-inferiority analysis. A common error in reporting clinical trial results is not correctly distinguishing between clinical and statistical significance.

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