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A Brief History of Childhood Tuberculosis 

A Brief History of Childhood Tuberculosis
Chapter:
A Brief History of Childhood Tuberculosis
Author(s):

Peter R. Donald

DOI:
10.1093/med/9780190220891.003.0001
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date: 18 November 2018

Under epidemic conditions, children are among the chief victims of tuberculosis, suffering a greater morbidity and mortality during early childhood than people at any other age in life. Under such conditions, early post-mortem and clinical studies were carried out by pioneer pediatricians like Marie-Jules Parrot that laid the foundation of our knowledge of childhood tuberculosis. George Küss, Heinrich Albrecht, and Anton Gohn, among others, confirmed Parrot’s findings that the enlargement of the mediastinal lymph nodes during primary tuberculosis infection is always preceded by primary infection taking place in a lung focus, usually subpleural. Tuberculin skin testing developed by von Pirquet and Mantoux enabled the clinical documentation of tuberculosis infection and, with chest radiography, made possible the diagnosis and study of disease progress or regression. By 1920, the tools were available to study the natural history of tuberculosis in children.

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