Qualified, late specialism training

The adult brain produces new neurons. In an exceptional process of structural plasticity, resident stem cells lifelong generate new neurons in at least two brain regions, thereby providing a particular type of flexibility and adaptability. Adult neurogenesis is involved in learning and memory processes in the hippocampus and, if impaired, might contribute to a number of disorders, including major depression, schizophrenia and dementia. "Adult neurogenesis 2" comprehensively covers all aspects of this rapidly growing area of neuroscience with topics ranging from neural stem cell biology and neuronal development over particular aspects of neurogenesis in the hippocampus and the olfactory system, including its regulation and function, to questions of neurogenesis outside these two canonical neurogenic regions and evolutionary and -- importantly -- medical issues. ...Less

This resource summarizes the advances in our understanding of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), as well as the potential relationship between the two. ...Less

The Atlas of X-Linked Intellectual Disability Syndromes is a comprehensive summary of the clinically distinctive disorders caused by genes on the X chromosome. Each syndrome is defined and information is provided on somatic features, growth and development, neurological signs, cognitive performance, imaging and other laboratory findings, and when possible, the nature and localization of the responsible gene. Craniofacial and other somatic findings are extensively illustrated. A differential matrix accompanies each syndrome description to assist the reader in identifying other X-linked syndromes with overlapping features. Individual syndrome entries are supplemented with nineteen appendices that identify syndromes with common features and provide the location or mapping limits and function of the responsible genes. ...Less

Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 100 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. ...Less

Autonomy and Mental Disorder explores the nature and value of autonomy with reference to mental disorder, reflects on instances of mental disorder where autonomy is apparently compromised, and offers a systematic discussion of the underlying presuppositions of the present autonomy debates. ...Less

Dysmorphology is the study of congenital malformations and is one of the core areas of clinical genetics. Often the first professional seeing these birth defects is a pediatrician, who notices, for example, that the ears may be rather low set. While in itself minor, this physical sign may indicate a malformation that will be accompanied by other serious genetic disorders. Does the sign, or does it not, indicate an underlying syndrome? The aim of this resource is to provide a practical solution to questions like these. ...Less

This resource takes a critical insider's look at commonly held views about the diagnosis and management of depression, and argues that our belief in depression as a medical condition is based on commercial, professional, organisational and cultural factors, which all combine to sustain the popularity of depression as a concept, which is based more on our values than on science. ...Less

In this highly topical resource, the first ever on binge drinking, the authors look at the UK and its alcohol problem, and review the role of alcohol in Britain in the past 1500 years. Binge Britain looks at why our drinking culture is maintained and why politicians seem reluctant to act effectively to reduce the problem, as well as the power of the alcohol industry, and the huge amount of money it contributes in taxes. This resource provides an informed overview of recent developments in alcohol consumption and alcohol-related problems, together with a commentary on and critique of the development of recent policy and the national response to this policy. ...Less

How should we deal with mental disorder - as an "illness" like diabetes or bronchitis, as a "problem in living", or what? This resource seeks to answer such questions by going to their roots, in philosophical questions about the nature of the human mind, the ways in which it can be understood, and about the nature and aims of scientific medicine. ...Less

Now in its second edition, Brain Architecture is the continued exploration of how the brain works. At the very core of our existence, the brain generates our thoughts and feelings, directs our voluntary interactions with the environment, and coordinates all of the vital functions within the body itself. This long-overdue new edition explains this oftentimes daunting intricacy and exquisite detail. The first half of the book discusses the basic parts and how they work, presenting an overview of the nervous system at both the microscopic and macroscopic levels. The approach follows three classic lines of thought that proceed from simple to complex: the history of neuroscience research, the evolution of the nervous system, and the embryological development of the vertebrate central and peripheral nervous systems. The second half of the book outlines the basic wiring diagram of the brain and nervous system—how the parts are interconnected and how they control behavior and the internal state of the body. This is done within the framework of a new four-system network model that greatly simplifies understanding the structure-function organization of the nervous system. Written in clear and sparkling prose, beautifully illustrated, and thoroughly updated, Brain Architecture, Second Edition is must-read for anyone interested in the science of how the brain works. ...Less