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Is free will just an illusion? What is it in the brain that allows us to pursue our own actions and objectives? What is it about this organ that permits seemingly purposeful behaviour, giving us the impression we are free? This resource takes a journey into the brain to examine what is about known voluntary behaviour, and why it can go wrong. ...Less

This resource provides information for the management of disorders occurring during sleep and brings greater awareness to the treatment of sleep disorders, as well as treatments of neurological, medical, and psychiatric disorders. ...Less

The adult brain produces new neurons. In an exceptional process of structural plasticity, resident stem cells lifelong generate new neurons in at least two brain regions, thereby providing a particular type of flexibility and adaptability. Adult neurogenesis is involved in learning and memory processes in the hippocampus and, if impaired, might contribute to a number of disorders, including major depression, schizophrenia and dementia. "Adult neurogenesis 2" comprehensively covers all aspects of this rapidly growing area of neuroscience with topics ranging from neural stem cell biology and neuronal development over particular aspects of neurogenesis in the hippocampus and the olfactory system, including its regulation and function, to questions of neurogenesis outside these two canonical neurogenic regions and evolutionary and -- importantly -- medical issues. ...Less

This resource summarizes the advances in our understanding of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), as well as the potential relationship between the two. ...Less

Antipsychotic long-acting Injections provides a synthesis and broad picture of the place of LAIs in current clinical practice, and looks at both their advantages and disadvantages. ...Less

This atlas capitalises on novel diffusion MRI tractography methods to provide a comprehensive overview of connections derived from virtual in vivo tractography dissections of the human brain. ...Less

The Atlas of X-Linked Intellectual Disability Syndromes is a comprehensive summary of the clinically distinctive disorders caused by genes on the X chromosome. Each syndrome is defined and information is provided on somatic features, growth and development, neurological signs, cognitive performance, imaging and other laboratory findings, and when possible, the nature and localization of the responsible gene. Craniofacial and other somatic findings are extensively illustrated. A differential matrix accompanies each syndrome description to assist the reader in identifying other X-linked syndromes with overlapping features. Individual syndrome entries are supplemented with nineteen appendices that identify syndromes with common features and provide the location or mapping limits and function of the responsible genes. ...Less

Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 100 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. ...Less

This resource demonstrates that autism, like mental retardation, is a clinical presentation of numerous different diseases, many with genomic underpinnings. In this ground-breaking work, the authors explain in great detail how to clinically diagnose infants, children, adolescents and adults with autistic behavioral features and their psychiatric and neurological work-ups. ...Less

Autonomy and Mental Disorder explores the nature and value of autonomy with reference to mental disorder, reflects on instances of mental disorder where autonomy is apparently compromised, and offers a systematic discussion of the underlying presuppositions of the present autonomy debates. ...Less