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This resource provides information for the management of disorders occurring during sleep and brings greater awareness to the treatment of sleep disorders, as well as treatments of neurological, medical, and psychiatric disorders.Less

Diagnosis and treatment of acute stroke has advanced considerably in the past 2 decades. Most notably, in cases of ischemic stroke, intravenous alteplase has become the standard of medical treatment despite its multiple contraindications and limited time window. More recently, trials have proven that endovascular thrombectomy is superior to medical therapy alone, advancing the standard of care for patients who present with acute ischemic stroke from a large vessel occlusion and salvageable brain tissue. The treatment of hemorrhagic stroke now involves the use of novel pharmacological agents and advanced minimally invasive technology. Important changes have also occurred at the levels of hospital organization and treatment decision-making. Such changes in organization and designation of hospitals with distinct levels of stroke care and the variety of stroke protocols now requires team work of emergency medical services (EMS), Emergency Department, stroke neurologists, neurosurgeons, and neurointerventionalists. This book provides an overview of the modern medical and surgical options for the treatment of patients with acute ischemic and hemorrhagic strokes. The pivotal role of EMS in prehospital evaluation and triage of a stroke patient and the levels of stroke systems of care are discussed. In addition, the current guidelines on the management of acute stroke, with the focus on early care of acute stroke patients at the Emergency Department and the first 24 hours of hospital admission, are reviewed. Each chapter contains a discussion of common clinical scenarios including initial management steps, practical points, and common pitfalls.Less

Providing clinicians with the latest developments in research, this new edition of Alzheimer's Disease is a succinct and practical introduction to the diagnosis, evaluation, and management of Alzheimer’s disease. Part of the Oxford Neuropsychiatry Library series, this pocketbook contains 14 fully updated chapters on key topics such as pathophysiology, epidemiology, pharmacological treatments, and psychological symptoms. It also features new chapters on atypical presentations, end-of-life issues, and case vignettes to ensure the reader is fully equipped with the latest understanding of the possible causes of the disease, methods of diagnosis, and management techniques. A powerful tool for the practising clinician, this edition is an indispensable guide to the latest thinking about management of the disease.Less

Amyotrophic lateral sclerosis: Understanding and optimizing quality of life and psychological well-being presents a comprehensive and up-to-date review of the enhancement of the lives of people with amyotrophic lateral sclerosis (ALS) and their caregivers. ALS is a progressive, fatal neurodegenerative disorder. No current medical therapy can reverse or stop its progression, and the promotion of quality of life and psychological well-being is a central component of ALS care. Health care professionals who work in this field should incorporate attention to psychological, emotional, and relational aspects of the disease into their approach to care. This book provides some of the knowledge and direction necessary for optimizing the quality of care for individuals with ALS and their caregivers. Topics discussed include an ALS-centred view of quality of life, depressive features, anxiety, resilience, cognitive impairment, complementary and alternative medicines, and psychological research. Specific elements of ALS, such as end-of-life concerns and bulbar dysfunction, are described through the lens of their psychological impact. There is extensive discussion of the development of new psychological treatments, as well as the impact and incorporation of new technologies, with the goal of fostering optimal quality of life and psychological well-being as key parts of a holistic approach to care for the patients and for those who are close to such individuals.Less

This resource summarizes the advances in our understanding of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), as well as the potential relationship between the two.

Italian scientist, Angelo Mosso was widely recognized for his pioneering study in the nineteenth century of head injuries that exposed the brain to direct observation, and there has never been a translation through which his magnificent achievement could be recognized in English. Through this online resource, the modern reader can now gain a perspective on the remarkable insights Mosso gained into how behaviors as subtle as thinking about a subject or feeling an emotion can produce the changes in pulsations of the brain that he observed. This online resource begins with a brief summary of Mosso's life, work, and their relevance to modern methods. It emphasizes Mosso's role as a pioneer in brain imaging, but also as a pioneer in the eventual rise of cognitive neuroscience, which is then followed by the English translation, together with all of the plates and illustrations of the original volume.Less

This concise handbook provides practical, up-to-date clinical guidance on effective selection, prescription, and usage of antiepileptic drugs for patients with epilepsy in various medical conditions and in a variety of clinical contexts. This text discusses choosing drugs when faced with various medical comorbidities; how to correctly prescribe, titrate, and taper drugs; how to monitor drug efficacy and side effects; how to diagnose and manage toxicity; how antiepileptic drugs interact with other medications; and comprehensive coverage of current treatment options. Key Feature of this Manual Include… • A brief formal discussion of the basic pharmacology of each antiepileptic drug, with an emphasis on how to select and use anti-epileptic drugs in a variety of clinical contexts. • Discussions of antiepileptic drugs approved for epilepsy since 2009. • New research about already existing antiepileptic drugs. • References for further reading that are oriented toward utility in clinical practice. Antiepileptic Drugs: A Clinician's Manual fills an unmet need as a practical, patient-oriented reference and leads to improved patient care. Supported by practical, clinical knowledge and experience, this is the perfect guide for physicians looking to ensure safe practices in antiepileptic drug therapy. Less

This resource is a richly-illustrated guide to the performance and interpretation of EEG and management of epilepsy. This second edition has been thoroughly revised and updated, and features hundreds of detailed EEGs covering the science in extensive scope and detail, beginning with basic electronics and physiology, followed by EEG interpretation, epilepsy diagnosis, and ultimately epilepsy management. It also includes all basic classifications and definitions of seizures and epilepsy, making it the perfect clinical companion. Full-color EEG presentations are featured alongside easy-to-read syntheses of anatomy, physiology, and available treatment modalities. These detailed explanations of wave pattern, presentation, and treatment provide the most informed sense of clinical application and readiness, covering every type of seizure, both epileptic and non-epileptic.Less

This new resource is divided into sections based on the major peripheral nerves. It contains detailed illustrations of each nerve along with a discussion of its anatomy, followed by a thorough outline of the clinical conditions and entrapment syndromes that affect the nerve, including a list of the etiologies, clinical features, and electrodiagnostic strategies used for each syndrome. Routine and special motor and sensory nerve conduction studies are shown in an anatomical illustration. In addition, each muscle supplied by the peripheral nerve is illustrated showing the root, plexus, and peripheral nerve supply to the muscle and is accompanied by a corresponding human photograph.Less

Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research, and is now an intense growth area in behavioral and educational treatments. This resource provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders, including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology.Less

This resource demonstrates that autism, like mental retardation, is a clinical presentation of numerous different diseases, many with genomic underpinnings. In this ground-breaking work, the authors explain in great detail how to clinically diagnose infants, children, adolescents and adults with autistic behavioral features and their psychiatric and neurological work-ups.Less

This resource discusses the identification of potential therapeutic targets for autism that can be tested in genetic models and hopefully translated into novel, rational therapies. It provides a roadmap to multitude of relatively rare mutations that have been identified as causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, this resource aids the understanding of the pathophysiology of autism and ultimately to identifying novel treatments.Less

This new edition of Autonomic Failure features numerous new chapters and makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, thereby allowing more effective treatment. It provides a rational guide to aid in the recognition and management of autonomic disorders for practitioners from a variety of fields, including neurology, cardiology, geriatric medicine, diabetology, and internal medicine.Less

Autonomic Neurology focuses on clinical scenarios and presentation of clinical cases, organized into three sections. The first section reviews the anatomical and biochemical mechanisms of central and peripheral nervous system control of autonomic function, principles of autonomic pharmacology, and a clinical and laboratory approach to the diagnosis of autonomic disorders. The second section focuses on the pathophysiology and management of orthostatic hypotension, postural tachycardia, baroreflex failure; syncope, disorders of sweating, neurogenic bladder and sexual dysfunction, gastrointestinal dysmotility, and autonomic hyperactivity. The final section is devoted to specific autonomic disorders, including central neurodegenerative disorders; common peripheral neuropathies with prominent autonomic failure; painful small fiber neuropathies; autoimmune autonomic ganglionopathies and neuropathies; focal brain disorders; focal spinal cord disorders; and chronic pain disorders with autonomic manifestations.Less

This resource provides a framework for understanding the pathophysiology of diseases involving the vestibular system, and is divided into four parts: Anatomy and physiology of the vestibular system; Evaluation of the dizzy patient; Diagnosis and management of common neurotologic disorders; and Symptomatic treatment of vertigo.Less

This online guide is a concise overview of a selection of the most important contemporary electrophysiological techniques, their implementation, applications, and ways in which they can be combined and integrated with related neuroscience techniques. It does not obscure the relevant technical details with textbook neuroscience tutorials, and each chapter provides a concise overview of the underlying theory, a comprehensive description of equipment, materials, methods, data management and analysis, a troubleshooting guide, and a list of frequently asked questions. It provides a fundamental and accessible set of information intended to form a foundation prior to, during, and after hands-on experience and training, greatly facilitating the initial learning process and subsequent fine-tuning of technical details.Less

The central nervous system consists of gray matter structures, including the neocortex, basal ganglia, thalamus, and cerebellum, and an extensive array of connecting white matter tracts that allow the integration of the many functions mediated by the gray matter. Neuroscience, neurology, and behavioral neurology have tended to emphasize gray matter function and have left white matter disorders and the essential behavioral functions of white matter relatively unexplored. Individual diseases such as multiple sclerosis have been studied extensively, but an integrated view of the function of white matter and patterns of dysfunction occurring when white matter is affected has been lacking. In this resource, the author redresses this imbalance and provides a detailed discussion of the biology of white matter, the phenomenology of white matter diseases, and the pathological disturbances that affect primarily the white matter. The book discusses how great an effect white matter diseases have overall, contributing to many disease processes and providing the neurobiological basis for many cognitive disturbances.Less

The Behavioural Neurology of Antiepileptic Drugs is the first clinically oriented reference book on the use of antiepileptic drugs with a focus on their behavioural effects in both patients with epilepsy and patients with primary psychiatric conditions. This book provides a pocket-sized guide to assist neurologists in the use of antiepileptic drugs when treating patients with epilepsy and associated behavioural problems. Psychiatrists treating patients with affective, anxiety, and psychotic disorders will also find this compendium on the behavioural aspects of antiepileptic drugs as a useful tool for their clinical practice. The book is organized alphabetically by antiepileptic drug for easier information gathering, enabling physicians to use the text as a standalone reference in busy clinical settings, such as specialist epilepsy clinics or general psychiatry ward rounds. Particular care was taken in covering the breadth of medications used in modern epilepsy and psychiatry practice, including each drug’s indications, contra-indications, side-effects and important interactions. The underlying pharmacology is also presented to provide a quick refresher and background on the underlying mechanisms. Practical aspects related to prescribing and therapeutic drug monitoring are covered following the most up-to-date evidence based guidance. Each drug monograph closes with a section providing a visual rating in terms of antiepileptic indications, behavioural tolerability, interactions in polytherapy, and psychiatric use, again drawing on the existing evidence. A selected reference list is included to provide readers with the primary sources for clinically-relevant information presented in a concise way within each chapter.Less

This resource addresses the disorders presenting in children, adolescents and adults which may be mistaken for epilepsy or which are associated with epilepsy and can develop into or out of epileptic seizures. It features case reports and tables (especially those which address the differential diagnosis of epilepsy and the disorders discussed), and covers anxiety/hyperventilation attacks, psychogenic nonepileptic seizures, epileptic and nonepileptic encephalopathies, autism, autoimmune encephalopathies, Tourette's Syndrome, transient ischemic attacks, transient global amnesia, myoclonus, alcohol-related seizures, hyperekplexia and dyskinesia, stereotypical behaviors, organic personality disorder and episodic dyscontrol syndrome. Less

The core of the text of this book combines the theory and practice of determining brain death. The history and development of clinical criteria of brain death is revisited. The complex neurological evaluation and its pitfalls are discussed in great detail. Moreover, the many facets of brain death determination as well as its communication to family members are examined. These include cultures beliefs, bioethical problems, discussion with family members, and many of the issues associated with organ procurement. The process of organ procurement, which is separate from brain death determination, is also outlined, along with the role of an organ procurement coordinator. This monograph is exhaustively researched and provides answers to pressing and often repeated questions, in a chapter focused on 30 issues commonly encountered by physicians in determining brain death, maintaining the body in intensive care for organ donation, and dealing compassionately with family members and effectively with the media. Legal issues are also addressed here. The book includes several video clips pertaining to the neurological evaluation of brain death and accompanying pitfalls.Less