The Neurology of AIDS

The Neurology of AIDS (3 ed.)

Edited by Howard E. Gendelman, Igor Grant, Ian Paul Everall, Howard S. Fox, Harris A. Gelbard, Stuart A. Lipton, and Susan Swindells

Abstract

This resource discusses how neurological complications of progressive HIV-1 infection remain a common cause of morbidity even during widespread use of antiretroviral therapy (ART). It addresses how long-term resistance to ART, drug compliance, untoward drug side effects, a myriad of opportunistic infection, depression and other psychiatric disease manifestations, concomitant drug abuse, neuropathies, and an inability to clear viral reservoirs, explain, in large measure, disease progression and immune deterioration. It then covers the association with a number of psychiatric, muscle, nerve, infectious, as well as cognitive, behavioral, and motor disturbances seen in infected people, with a focus on the neurological complications, molecular and viral disease processes, cellular factors influencing viral replication therapeutic challenges, and the changing epidemiological patterns of disease.

Bibliographic Information

Publisher:: Oxford University Press

Print Publication Date:: Dec 2011

Print ISBN-13:: 9780195399349

Published online:: Sep 2012

DOI:: 10.1093/med/9780195399349.001.0001

Authors

Howard E. Gendelman, editor University of Nebraska Medical Center

Igor Grant, editor University of California, San Diego

Ian Paul Everall, editor University of Melbourne

Howard S. Fox, editor University of Nebraska Medical Center

Harris A. Gelbard, editor University of Rochester Medical Center

Stuart A. Lipton, editor Adjunct Professor, The Salk Institute for Biological Studies and The Scripps Research Institute

Susan Swindells, editor University of Nebraska Medical Center

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Front Matter
Section 1 HIV-1 Biology and Immunology
- 1.1 HIV-1 BiologySergey Iordanskiy and Michael Bukrinsky
- 1.2 HIV-1 ImmunologySabita Roy, Krishnakumar Devadas, Subhash Dhawan, and Shilpa Buch
- 1.3 ChemokinesRichard J. Miller
- 1.4 Viral and Host Genetic FactorsJennifer A. McCombe, Shaona Acharjee, M. John Gill, and Christopher Power
- 1.5 Genetic Susceptibilities for NeuroAIDSSrinivas Mummidi, Jason F. Okulicz, Edwina J. Wright, Weijing He, and Sunil K. Ahuja
Section 2 Innate and Cellular Immunity and Neurogenesis
- 2.1 Mononuclear PhagocytesKenneth C. Williams, William F. Hickey, Tricia H. Burdo, and Caroline Soulas
- 2.2 MicrogliaSunhee C. Lee
- 2.3 AstrocytesEtty N. Benveniste, Lisa N. Akhtar, and Brandi J. Baker
- 2.4 Adaptive ImmunityJessica A. L. Hutter-Saunders, Larisa Y. Poluektova, Subhash Dhawan, and Howard E. Gendelman
- 2.5 VaccinesMax V. Kuenstling, Eric J. Benner, and R. Lee Mosley
- 2.6 NeurogenesisJames B. Reinecke, Hui Peng, Yunlong Huang, Qiang Chen, and Jialin C. Zheng
Section 3 Blood-Brain Barrier and HIV CNS Entry
- 3.1 Blood-Brain Barrier Structure and FunctionWilliam A. Banks
- 3.2 Endothelial Cell Biology and HIV-1 InfectionMichal Toborek, Ibolya E. András, Cetewayo S. Rashid, Yu Zhong, and Shinsuke Nakagawa
- 3.3 Blood-Brain Barrier During NeuroinflammationYuri Persidsky and Servio H. Ramirez
- 3.4 Mechanisms of Viral and Cell Entry into the Central Nervous SystemEliseo A. Eugenin and Joan W. Berman
- 3.5 Monocyte-Macrophages and Viral Central Nervous System EntryGeorgette D. Kanmogne
Section 4 Cellular and Viral Neurotoxicity and Abused Drugs
- 4.1 Mononuclear Phagocyte Inflammation and NeurotoxicityAndrea Martinez-Skinner, Ari S. Nowacek, JoEllyn McMillan, and Howard E. Gendelman
- 4.2 Neurotoxicity of HIV-1 ProteinsManja Meggendorfer, Ina Rothenaigner, Bianca Tigges, Michelle Vincendeau, and Ruth Brack-Werner
- 4.3 HIV-1 and Tat Neuropathogenesis and Therapeutic TargetsWenxue Li, Guanhan Li, Joseph Steiner, and Avindra Nath
- 4.4 HIV-1 gp120Shu-ichi Okamoto, Marcus Kaul, Ian Paul Everall, Eliezer Masliah, and Stuart A. Lipton
- 4.5 HIV-1 and CannabinoidsGuy A. Cabral and Erinn S. Raborn
- 4.6 HIV-1 and MethHoward S. Fox
- 4.7 HIV-1 and OpioidsToby K. Eisenstein, Jessica Breslow, Changcheng Song, Mathew J. Finley, William D. Cornwell, Sumedha Chugh, Joseph J. Meissler, and Thomas J. Rogers
- 4.8 HIV-1 and CocaineShilpa Buch, Honghong Yao, and Sabita Roy
Section 5 Animal Models
- 5.1 Simian Immunodeficiency VirusM. Christine Zink, Joseph L. Mankowski, David R. Graham, Lucio Gama, and Janice E. Clements
- 5.2 Feline Immunodeficiency VirusRick B. Meeker
- 5.3 Caprine Arthritis Encephalitis Virus and VisnaValgerdur Andrésdóttir, Sigurbjörg Torsteinsdóttir, and Gudmundur Georgsson†
- 5.4 TransgenicsSulie L. Chang and Marley D. Kass
- 5.5 Murine Models for NeuroAIDSLarisa Y. Poluektova
- 5.6 Simian Immunodeficiency Virus and OpiatesShilpa Buch, Shannon Callen, Paul Cheney, and Anil Kumar
- 5.7 SIV and FIV Models of Peripheral NeuropathyVictoria A. Laast, Gigi Ebenezer, Justin C. McArthur, and Joseph L. Mankowski
- 5.8 Animal Models and BioimagingEva-Maria Ratai, Margaret R. Lentz, and R. Gilberto González
Section 6 Personal Perspectives in Living with HIV/AIDS
Section 7 Clinical and Pathologic Manifestations of Disease
- 7.1 Perspective on HIV CNS InfectionsRichard W. Price
- 7.2 HIV-Associated Neurocognitive DisordersIgor Grant and Ned Sacktor
- 7.3 The CNS in Acute and Early InfectionSerena S. Spudich
- 7.4 HIV-1 NeuropathologyBenjamin B. Gelman and David J. Moore
- 7.5 Peripheral NeuropathyKathryn J. Elliott, Justin C. McArthur, and David M. Simpson
- 7.6 Spinal Cord DiseaseMichael C. Previti and Christina M. Marra
- 7.7 MyopathyJessica Robinson-Papp, Kenneth A. Fox, David M. Simpson, and Susan Morgello
- 7.8 AgingVirawudh Soontornniyomkij and Cristian L. Achim
- 7.9 AddictionR. Douglas Bruce
Section 8 Pathogenesis of Comorbid Conditions
- 8.1 NeuroAIDS as an Inflammatory DisorderDenise R. Cook*, Stephanie A. Cross*, Samantha S. Soldan, and Dennis L. Kolson
- 8.2 Neuronal Injury, White Matter Disease, and Neurotrophic FactorsT. Dianne Langford, Ian Paul Everall, and Eliezer Masliah
- 8.3 Pathobiology of HIV-related NeuropathiesNicholas W. S. Davies and Bruce J. Brew
- 8.4 CNS ComorbiditiesGeorgette D. Kanmogne and David B. Clifford
- 8.5 Opportunistic InfectionsJoseph R. Berger and Bruce A. Cohen
- 8.6 Progressive Multifocal LeukoencephalopathyMaria G. Chiara and Eugene O. Major
- 8.7 NeoplasmsAlexis Demopoulos and Lauren Abrey
- 8.8 Hepatitis CLi Ye and Wenzhe Ho
- 8.9 HIV and Psychiatric ComorbiditiesTimothy B. Nguyen and Ian Paul Everall
Section 9 Diagnostics and Biomarkers
- 9.1 BioimagingLinda Chang, Ute Feger, and Thomas M. Ernst
- 9.2 Magnetic Resonance ImagingTerry L. Jernigan, Sarah L. Archibald, and Christine Fennema-Notestine
- 9.3 Psychological EvaluationsJordan Elizabeth Cattie, Steven Paul Woods, and Igor Grant
- 9.4 Viral and Cellular Biomarkers During Antiretroviral TherapyScott L. Letendre and Ronald J. Ellis
- 9.5 Viral DynamicsDavey M. Smith and Ronald J. Ellis
- 9.6 Viral Clades: Role In Hiv NeuropathogenesisWenxue Li and Avindra Nath
- 9.7 Proteomics and BiomarkersGwenael Pottiez, Jayme Wiederin, and Pawel Ciborowski
Section 10 Children and Adolescents
- 10.1 Clinical and Pathological Features of HIV-1 Encephalopathy in Children and AdolescentsMark Mintz, Leroy R. Sharer, and Lucy A. Civitello
- 10.2 Infants, Children, and Adolescents: Nervous System Disease in the Era of Combination Antiretroviral TherapyAnnelies Van Rie and Anna Dow
- 10.3 Psychosocial Aspects of Neurological Impairment in Children with AIDSLori Wiener and Claude Mellins
- 10.4 Growing up with HIV DiseaseShirley F. Delair, Leslie K. Serchuck, and Lynnae Schwartz
Section 11 Antiretroviral and Adjunctive Therapies
- 11.1 Current Concepts in the Treatment of HIV Infection with Focus on Brain DiseaseSusan Swindells and Uriel Sandkovsky
- 11.2 Pharmacology of Antiretroviral TherapiesScott L. Letendre, J. Allen McCutchan, Ronald J. Ellis, Brookie M. Best, and Edmund V. Capparelli
- 11.3 Treatment of Opportunistic Infections Associated with Human Immunodeficiency Virus InfectionDavid B. Clifford
- 11.4 Nanoformulated MedicinesUpal Roy, Shantanu Balkundi, JoEllyn McMillan, and Howard E. Gendelman
- 11.5 Antiretroviral NanotherapiesMadhavan P. N. Nair and Zainulabedin M. Saiyed
- 11.6 Adjunctive MedicinesHarris A. Gelbard and Stuart A. Lipton
Section 12 Psychiatry and Psychobiology
- 12.1 Psychiatric DisordersJ. Hampton Atkinson, Nichole A. Duarte, and Glenn J. Treisman
- 12.2 Neurocognition in HIV and Substance Use DisordersAndrew J. Levine, Raul Gonzalez, and Eileen M. Martin
- 12.3 Psychobiology of Risk BehaviorDavid G. Ostrow
- 12.4 Everyday Impact of HIV-Associated Neurocognitive DisordersThomas D. Marcotte, J. Cobb Scott, Charles H. Hinkin, and Robert K. Heaton
- 12.5 Facing Legal and Ethical Challenges in the Treatment of AIDSWarren B. Treisman and Glenn J. Treisman
- 12.6 Neuropsychological TestingKevin R. Robertson, Kevin J. Liner, Michelle Ro, and Robert K. Heaton
- 12.7 The impact of HIV Subtype AND Cultural and Sociodemographic Factors on HIV-1 Infection and Associated Neuropathogenesis in AfricaAdelina Holguin, Damien C. Tully, and Charles Wood
End Matter
- Index

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The Neurology of AIDS (3 ed.)

Edited by Howard E. Gendelman, Igor Grant, Ian Paul Everall, Howard S. Fox, Harris A. Gelbard, Stuart A. Lipton, and Susan Swindells

Abstract

Bibliographic Information

Authors

Contents